RELATIONSHIPS BETWEEN PHYSICAL FUNCTIONING AND ADHERENCE IN WOMEN WITH BREAST CANCER RECEIVING ENDOCRINE THERAPY

Name of Authors: Jennifer Marx, Yehui Zhu, Susan M. Sereika, Amanda Gentry, Rachelle S. Brick, and Catherine M. Bender Faculty Mentor: Yehui Zhu and Catherine M. Bender Department of Health and Community Systems, University of Pittsburgh School of Nursing, 3500 Victoria Street, Pittsburgh, PA 15213

Background: Aromatase inhibitor (AI) therapy is recommended by the National Comprehensive Cancer Network guideline for post-menopausal women diagnosed with estrogen receptor-positive breast cancer, yet poor medication adherence is common. Few studies have investigated whether patients with poor AI adherence have worse physical functioning. The purpose of this secondary analysis is to examine correlations between physical functioning and adherence in AI therapy. Methods: A medication event monitoring system (MEMSCap) was used to record the date and time patients opened their medication vial to take their medication. The percentage of days patients correctly took their AI were computed for the first and second 180 days of therapy. Physical functioning in the past 4 weeks was measured by a subscale from the Short Form Health Survey 36 at pre-AI initiation, 6 months post-initiation and 12 months post-initiation. The subscale is comprised of 10 items scaled from 0 (significant limitations) to 3 (no limitations). Spearman’s rho correlation was performed to examine the relationship between physical functioning at pre-AI initiation and adherence rates for the first and second 180 days post-AI initiation. Results: Participants (n=286) were 62 years of age on average, mostly white (94%), and diagnosed with stage I breast cancer (67.1%). Weak but significant correlations were found between lower levels of adherence rate for the first 180 days and limitations in vigorous activities, running, lifting heavy objects, and participating in strenuous sports (r=0.133; p=0.027), ability to climb one flight of stairs (r=0.142; p=0.019), and ability to bend, kneel, or stoop (r=0.119; p=0.050). Similar relations were found between lower adherence levels for the second 180 days and limitations in ability to climb one flight of stairs (r=0.200; p=0.002), and ability to bend, kneel, or stoop (r=0.190; p=0.004). Conclusion: Our findings suggest that physical functioning limitations before AI therapy may be related to AI adherence.


Additional Abstract Information

Presenter: Jennifer Marx

Institution: University of Pittsburgh School of Nursing

Type: Oral

Subject: Nursing

Status: Approved


Time and Location

Session: Oral 9
Date/Time: Fri 4:40pm-5:00pm
Location: Old North 211
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