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Personal and Household Correlates of Helicobacter pylori Infection Among Schoolchildren in Ziway, Central Ethiopia

Kayla Schacher(1), Sosina Walelign(2), Mehret Tesfaye(2), Kassu Desta(2), Aster Tsegaye(2), and Dr. Bineyam Taye(1) (1) Department of Biology, Colgate University, 13 Oak Dr. Hamilton, NY 13346 (2) Department of Medical Laboratory Science, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Investigating distinct individual- and household-level risk factors for acquiring Helicobacter pylori (H. pylori) infection can inform disease prevention efforts and implicate possible routes of transmission. This study determined the magnitude of H. pylori infection among schoolchildren in central Ethiopia and identified personal and household correlates of H. pylori infection status. A total of 434 schoolchildren participated in our cross-sectional study in Ziway, Ethiopia. Infection status was assessed using antigen and antibody rapid tests. Demographic and lifestyle information was obtained from parents via an interviewer-led questionnaire. Univariate and multivariate logistic regressions were performed to assess the relationships between identified factors and H. pylori infection. The prevalence of H. pylori infection was 65.7% (285/434). Of the personal variables assessed, the age group 10-14 years was found to be significantly associated with higher odds of H. pylori infection in univariate analysis (COR=2.22, 95% CI: 1.06-4.66, p=0.03) and remained positively correlated after adjusting for confounding factors (AOR=2.07, 95% CI: 0.98-4.39, p=0.06). The age group 5-9 years showed a borderline significant correlation with positive infection status (COR=1.88, 95% CI: 0.91-3.89, p=0.09). Of the household-level factors explored, having a traditional pit or no toilet was found to be significantly associated with 3.93-fold higher odds of H. pylori infection (AOR=3.93, 95% CI: 1.51-10.3, p=0.01), while the presence of smokers in the household was associated with 68% lower odds of infection (AOR=0.32, 95% CI: 0.11-0.89, p=0.03). Waste disposal in pits or fields showed a borderline significant association with negative infection status after adjusting for confounding variables (AOR=0.61, 95% CI: 0.37-1.02, p=0.06). This study from a developing country provides additional support for older age as a personal risk factor for H. pylori infection and identifies household factors related to socioeconomic status and sanitation as correlates of childhood infection status.


Additional Abstract Information

Presenter: Kayla Schacher

Institution: Colgate University

Type: Poster

Subject: Microbiology

Status: Approved


Time and Location

Session: Poster 1
Date/Time: Thu 8:30am-9:50am
Location: Poster Location TBA