Assessing Cortical Dopamine Transmission in a Genetic Rat Model of ADHD

Author: Carina Hicks Faculty: Dr. Deranda Lester and Dr. Helen Sable Department: Psychology Institution: The University of Memphis, 3720 Alumni Ave, Memphis, TN 38152

Attention-Deficit Hyperactivity Disorder (ADHD) is characterized by symptoms such as inattention, hyperactivity, and compulsive behavior.  ADHD has a strong genetic basis, as heritability is associated with 70-80% of child ADHD cases and 30-40% of adult cases.  Identifying specific genetic causes can help identify genetic risk and vulnerable populations while also shedding light on neural alterations underlying ADHD symptoms.  Recent clinical studies have identified the LPHN3 gene as a candidate, and rats with this gene knocked out have shown to be more impulsive.  Given that dopamine transmission in the PFC is often altered in ADHD, the proposed study aims to assess the neurochemical functioning in the PFC of LPHN3 knockout rats.  Specifically, we will use in vivo fixed potential amperometry to quantify PFC dopamine release before and after administration of the dopamine agonist nomifensine, which functions similarly to commonly prescribed ADHD medications.  We hypothesize that LPHN3 KO rats will exhibit hypodopaminergic transmission, with lower percent changes following nomifensine administration, relative to wildtype control rats.  The results of the proposed study will improve understanding of the role the LPHN3 gene plays in neural development, particularly related to pathologies associated with ADHD. 

Additional Abstract Information

Presenter: Carina Hicks

Institution: University of Memphis

Type: Poster

Subject: Psychology

Status: Approved

Time and Location

Session: Poster 10
Date/Time: Wed 1:30pm-2:30pm
Session Number: 6551