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Shania Bailey, and Dr. Veera Holdai, Department of Mathematics and Computer Science, Salisbury University, 1101 Camden Ave, Salisbury, MD 21801
Palliative radiation therapy is a growing field within medicine focused on relieving pain as a cause of bone metastases from a wide variety of primary cancer types. This retrospective study conducted is primarily focused on comparing the effectiveness of two regimens (8 Gy x 1 vs. 3 Gy x 10) of palliative radiation for bone metastases administered in January of 2018 through September of 2019 at Peninsula Regional Medical Center (PRMC), in Salisbury, Maryland. Patients were selected for this study if they met numerous requirements selected from the Radiation Therapy Oncology Group (RTOG) study number 97-14. Specifically, this study focused on the survival analysis comparing these two groups, as well as the change in Eastern Cooperative Oncology Group (ECOG) Performance Status and pain scores of the patients from their initial consultation, to one month following treatment. In concordance with previous research studies, it was hypothesized that there will be no differences in performance status or survival analysis outcome between the two regimens. Survival analysis, and Mann-Whitney paired t-tests were performed in RStudio. Differences were considered statistically significant when the p-value was computed to be less than 0.05. It was statistically supported that there was no difference in the treatment regimens in regard to survival time and pain scores, but there was a significant difference in ECOG scores. The sample size for this retrospective chart review is 64 patients, with 4 patients receiving 8 Gy and 60 patients receiving 30 Gy. With a larger sample size, and a multi-institutional representation of patients, this analysis may provide a more accurate comparison of treatment regimens.
Presenter: Shania Bailey
Institution: Salisbury University
Type: Poster
Subject: Mathematics
Status: Approved
