Hydrazone Condensation Reactions on Self Assembling Peptide Surfaces

Katherine Eighmy, Philip Scali, and Dr. Jillian Smith-Carpenter, Department of Chemistry and Biochemistry, Fairfield University 1073 N Benson Road, Fairfield, CT 06824

In the field of supramolecular chemistry, work is being done to characterize the reactivity of self-assembling peptides. 
Our project specifically focuses on studying the reactivity of these supramolecular surfaces. Previous results from our lab, involving the KLVFFAL peptide, have characterized a hydrazone condensation reaction on the nanofiber surface. In the current study we explore the aldehyde reactivity on the surface of self-assembled peptide structures. Our project quantifies the reaction between a hydrazide dye and an aldehyde-modified peptide to create a fluorescent nanofiber. Optimization of the hydrazone condensation reaction by altering pH and reacting aldehydes will lead to a better understanding of the reactivity of supramolecular surfaces. We will use HPLC analysis and MALDI-ToF mass spectrometry to characterize the supramolecular reactivity. Characterization of reactions on the surface of supramolecular structures will allow us to design further experiments in the biomaterials field.

Additional Abstract Information

Presenters: Katherine Eighmy, Philip Scali

Institution: Fairfield University

Type: Poster

Subject: Biochemistry

Status: Approved

Time and Location

Session: Poster 1
Date/Time: Mon 1:30pm-2:30pm
Session Number: 2156