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Retrospective Analysis of Porcine Circovirus 2 and Porcine Circovirus 3 in the U.S. Swine Industry

Christa Heffern, 614 Billy Sunday Rd Ames, IA 50014 Pablo Pineyro, Veterinary Diagnostic and Production Animal Medicine, 1850 Christensen Dr, Ames, IA 50011 Rodger Main, Veterinary Diagnostic and Production Animal Medicine, 1850 Christensen Dr, Ames, IA 50011 Eric Bush, National Animal Health Monitoring System (NAHMs) Margaret Parker, National Animal Health Monitoring System (NAHMs) Jean Paul Cano, Pig Improvement Company (PIC) Jack Creel, Merck Animal Health

Porcine circovirus 3 (PCV3) virus was recently described in the swine industry worldwide. Although it is considered a new member of the circovirus family, it is believed that it is not a newly emerging pathogen but has been circulating undetected while before its first description. During its first description, PCV3 was first found associated with reproductive and respiratory diseases in pigs. Porcine circovirus 2 (PCV2) is one of the most devastating and economically significant diseases affecting the swine industry worldwide. In 2006, a commercial vaccine became available worldwide and alleviated the clinical impact of this virus. However, this vaccine does not prevent viral circulation. Thus, this virus still remains highly prevalent and has shown tremendous genetic variation over the years. My research is focused on evaluating the presence of PCV3 in swine serum before its first description in 2015. I obtained a pool of 8000 serum samples in collaboration with the National Animal Health Monitoring System (NAHMS) from national surveillance held in 2000, 2006, and 2012. Samples were sorted by production age and aliquot for qPCR analysis. Fifteen representative sera per farm were pooled in 3 pools of 5 for PCV2 and PCV3 detection by qPCR. All samples were submitted to the ISU-VDL for PCR detection. Finally, the results were aggregated by farm and state, and the national prevalence was determined. Preliminary results showed that PCV3 was highly prevalent since 2000. Also, this virus was co-circulating with PCV2 in the swine population in the US. In conclusion, PCV3 was circulating in the US swine population before its first description. My future work includes analyzing the genetic evolution of PCV3 and PCV2 since 2000 and evaluates the national distribution of its prevalence.




Additional Abstract Information

Presenter: Christa Heffern

Institution: Iowa State University

Type: Poster

Subject: Animal Sciences

Status: Approved


Time and Location

Session: Poster 1
Date/Time: Mon 1:30pm-2:30pm
Session Number: 2005