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Active Compound M11 of Prairie Turnip Extract Regulates the Expression of Genes on Intercalated Disks in Neonatal Rat Cardiomyocytes

Tiffany Braun, Anna Sorenson, and Quinten Vasa, Dr. Paul Weber and Dr. Daniel Jung, Biology and Chemistry Departments, Briar Cliff University, Sioux City, IA, 51104

Prairie turnips (Psoralea esculenta) are found in the prairies of Iowa and have been used as a good source of various bioactives by Native Americans. A collaboration of labs at this institution have identified the active compound M-11. This compound exhibits antioxidant and antibacterial activity. Recently, research in this lab showed the anti-inflammatory activity of this compound. Anti-inflammatory activity in macrophages were due to the expression of Aryl hydrocarbon receptor (AhR), which is known to induce many anti-inflammatory genes. Many cardiac diseases including tachycardia could be due to the overexpression of junction proteins in intercalated disks. Research in other labs showed that AhR regulates the expression of junction proteins including plakoglobin and CX43. Thus, we hypothesized that treatment of M-11 in neonatal rat cardiomyocytes may regulate the expression of plakoglobin and CX-43. This was tested by analyzing the plakoglobin and CX43 genes by Real-time PCR analysis with specific primers. The data from this study suggests that M-11 is indeed regulating the expression of these genes.  

 




Additional Abstract Information

Presenters: Tiffany Braun, Anna Sorenson, Quinten Vasa

Institution: Briar Cliff University

Type: Poster

Subject: Biochemistry

Status: Approved


Time and Location

Session: Poster 1
Date/Time: Mon 1:30pm-2:30pm
Session Number: 2141