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Cloning and Characterization of CRISP Transcripts from Snake Venom

Paulina Kowalski and Dr. Ying Jia, Department of Biology, University of Texas Rio Grande Valley, 1 W University Blvd, Brownsville TX 78520

The CAP (CRISP, antigen 5 and Pr-1) protein superfamily occur in a great variety of species. Cysteine-rich secretory proteins (CRISPs) are a subgroup of this superfamily that, like many other toxins, show potential in their biological and pharmaceutical functions. CRISPs are found in a wide variety of animal tissue and snake venoms, where they inhibit both potassium-induced smooth muscle contraction and cyclic nucleotide-gated channels. From the CRISPs studied, the few that have been functionally characterized were reported to exhibit a multitude of activities. However, many venom CRISPs have yet to be assigned specific functions. 

Therefore, to explore the biological and pharmaceutical functions of venom CRISP, we cloned and characterized CRISP transcripts in the venom extracted from a Western diamondback rattlesnake (Crotalus atrox). The results obtained from this research would be supplemental for future attempts at unlocking the full potential of CRISPs.




Additional Abstract Information

Presenter: Paulina Kowalski

Institution: University of Texas Rio Grande Valley

Type: Poster

Subject: Biology

Status: Approved


Time and Location

Session: Poster 3
Date/Time: Mon 4:30pm-5:30pm
Session Number: 3126