Trends and Racial Disparities in US Liver Cancer Mortality, 1999 to 2018

Rachelle Monteau and Fumiko Chino, MD Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065

In the United States, most cancers have had declining mortality rates in the past 30 years, however, liver cancer (LC) mortality has increased. Prior research has shown racial disparities with Asian Americans having the highest rates of incidence and mortality, primarily driven by Hepatitis B (HBV), however, it is unclear how this has changed today. Data were collected from the CDC WONDER database containing all US cancer deaths. Age-adjusted mortality was calculated per 100,000 for LC and trended from 1999-2018. LC mortality by race/ethnicity, sex, and age was determined.  


From 1999-2018, yearly LC deaths increased from 12,382 to 27,686, while the population increased from 279.0 to 327.2 million. Overall, liver cancer mortality (LCM) increased from 4.5 to 6.7 per 100,000 (trend p<0.001) and was worse in males than females (9.7 vs 4.1 per 100,000 in 2018, respectively). LCM increased in all racial/ethnic groups except for Asians where it declined (White 4.2 to 6.4, 52% increase; non-Hispanic 4.4 to 6.4, 45% increase; Black 5.9 to 8.3, 41% increase; American Indian 5.5 to 7.6, 38% increase; Hispanic 7.2 to 9.2, 31% increase; Asian 10.2 to 8.1, 21% decrease; all trends p<0.001). In Asians, younger age groups had larger proportional decreases in LCM (63.6% age 0-44, 34.0% age 45-64 relative decrease) compared to older groups (10.7% age 65-84 relative decrease).


Since 2018, Hispanic and Black patients have the highest LCM, and Asian LCM has decreased, perhaps reflecting the benefit of HBV vaccination (first available in 1982). This study highlights new racial disparities and presents opportunities for targeted outreach to underserved communities. In addition to vaccination, prevention efforts should include early diagnosis and treatment of viral hepatitis as well as measures to control obesity and decrease alcohol and tobacco use. Equitable access to cancer treatment is also essential to decrease LCM.

Additional Abstract Information

Presenter: Rachelle Monteau

Institution: City University of New York- City College

Type: Oral

Subject: Nursing & Public Health

Status: Approved

Time and Location

Session: Oral 5
Date/Time: Tue 12:30pm-1:30pm
Session Number: 526
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