Morphology changes in hippocampal astrocytes during circadian rhythms

Saad Ahmad and Annalisa Scimemi, Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222

The circadian rhythm affects behavior and physiology in many animal species. Our previous work in mice showed that within the hippocampus, a subordinate circadian oscillator, astrocytes change their proximity to excitatory synapses. Here we obtain 3D reconstructions of biocytin-filled hippocampal astrocytes processed with protein retention expansion microscopy and imaged using two-photon laser scanning microscopy. Our findings identify the subtle changes in astrocyte morphologies that encode information about time-of-day in hippocampal astrocytes. These findings shed light on fundamental mechanisms that allow the function of hippocampal circuits to adapt to different times of the day.

Additional Abstract Information

Presenter: Saad Ahmad

Institution: University at Albany - State University of New Yor CURCE

Type: Poster

Subject: Biology

Status: Approved

Time and Location

Session: Poster 3
Date/Time: Mon 4:30pm-5:30pm
Session Number: 3113