Effect of TIMP-1 Levels, MMP-1 Levels, and Healing Times on the Wound Surface Area

Aarini Panzade, Richard Schugart, Department of Mathematics, Western Kentucky University, 1906 College Heights Blvd, Bowling Green, KY 42101

     Matrix metalloproteinases (MMPs) are enzymes that degrade all kinds of extracellular matrix proteins during the wound-healing process. TIMP-1 is a tissue inhibitor of metalloproteinases (MMPs). In this work, we are investigating how MMPs and TIMPs, and the ratio of MMPs to TIMPs affect the wound surface area and the healing time. The data used for this work was of sixteen patients with diabetic foot ulcers in which measurements were taken of MMPs and TIMPs during a 12-week period. A multilinear regression analysis was performed on the interaction terms of different variables and compared to the wound surface area and compared to the regression analysis done on just the individual variables and other interaction terms. It was concluded that the multilinear regression analysis done by the interaction terms of MMP – 2 Latente and MMP – 9 Latente was the most beneficial to the wound surface area than the one done on other combinations of variables.

Additional Abstract Information

Presenter: Aarini Panzade

Institution: Western Kentucky University

Type: Poster

Subject: Computer Science

Status: Approved

Time and Location

Session: Poster 5
Date/Time: Tue 12:30pm-1:30pm
Session Number: 4016