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Sierra Hart, Isaac Preston, Dallin Leatham, Parker Ferguson, Brian Farnsworth, Dr. Don Davies and Dr. Tracy Covey. Department of Chemistry and Biochemistry, Weber State University. 3848 Harrison Blvd, Ogden, UT 84403.
The term chalcone refers to molecules with the structure trans 1,3-diphenylprop-2-en-1-one. Biological chalcones and chalcone derivatives display anti-tumor, anti-fungal, anti-inflammatory and antibiotic properties. To understand the role of the chalcone structure in tumor cessation, derivatives to the original chalcone were synthesized using various aldol condensation reactions. To determine the efficacy of a given structure, the compound was used to treat HeLa and HEK-293 cells lines and an LD50- or the concentration of chalcone required to kill half of the cells, was calculated. Correlations between the structure and activity suggest that a Michael reaction occurs at the cell and indicate that that an aromatic ring at C3 is likely necessary. Further research will help to predict the structures of more cytotoxic compounds.
Presenter: Sierra Hart
Institution: Weber State University
Type: Poster
Subject: Chemistry
Status: Approved
