Staphylococcus aureus and Human Neutrophil Interactions

Sarah Mad Plume and Dr. Jovanka Voyich, Department of Microbiology and Immunology, Montana State University, 109 Lewis Hall, 59717-3520

Staphylococcus aureus is a major human pathogen that can colonize in superficial wounds and can even invade deeper into the human body and cause life threatening infections. The clinical significance of S. aureus has dramatically increased over the years due to the emergence of antibiotic resistant strains, making it harder to treat patients infected with this pathogen. Bacteria have virulence genes that are controlled by the SaeR/S two-component system, and Dr. Voyich’s lab has preliminary data that indicates a mutation in this system could alter its gene expression. We investigated how mutations in the SaeR/S system of S. aureus impact its virulence gene expression. Although the pandemic interrupted our research, it was determined through previous studies and literature reviews that the SaeR/S two-component system in S. aureus is vital for the evasion of human neutrophils. The findings in this study could potentially lead to more insight on how to treat these infections caused by this bacteria. 


Additional Abstract Information

Presenter: Sarah Mad Plume

Institution: Montana State University Bozeman

Type: Poster

Subject: Microbiology

Status: Approved

Time and Location

Session: Poster 8
Date/Time: Tue 5:00pm-6:00pm
Session Number: 5636