3D Printed Scaffolds to Aid Against Bone Defects

Kevin Ghale, Mohammad Khaled, Mohamed Shabeel Abdul Samad and Dr. Morshed Khandaker, Department of Engineering and Physics, University of Central Oklahoma, 100 N University Dr, Edmond OK 73034.

In the United States, 1.5 million people suffer from bone defects yearly, and with roughly about 10 million individuals over the age of 50 with osteoporosis, the numbers will grow yearly. Bone defect is the lack of bone tissue in a body area where the bones should be present. These bone defects are related to osteoporosis, fractures, bone malformation and other bone diseases. The best treatment for bone defects is the application of bone grafts, where bones from another part of the body is taken out and added to the affected bone area to allow the bone cells to repair it. There are also many other different kinds of grafts but the method itself could adversely affect the part of the body where the bone was taken from. In addition, bone grafts require finding matching bone types with the right mechanical properties and with enough of the bone cells to be spared for the affected part of the body. A safer way would be to add a compatible outside element to take care of the bone defects, like adding a biodegradable scaffold that hosts cells that could enhance the bone cells to repair the bones. Different bones have different mechanical characteristics, and with the scaffold being 3D printed through fused deposition modeling, it gives us the flexibility of making the scaffold to be in whatever shape and size is required to match the mechanical properties of the affected body part's bone. For instance, we were able to attain a compressive strength and modulus of 0.57 MPa and 0.52 MPa for poly(ethylene glycol) diacrylate and 1.44 MPa and 0.90 MPa for a hybird scaffold of poly(ethylene glycol) diacrylate and polycaprolactone respectively when we were trying to match the scaffolds' mechanical properties to that of human knee cartilage.

Additional Abstract Information

Presenters: Kevin Ghale, Mohamed Samad, Mohammad Khaled

Institution: University of Central Oklahoma

Type: Poster

Subject: Engineering

Status: Approved

Time and Location

Session: Poster 6
Date/Time: Tue 2:00pm-3:00pm
Session Number: 4586