Mathematical Model of Fluorescent Silica Nanoparticle Diffusion in Tumor Extracellular Matrix Mimic

Lyan Basora Dorville, Dr. Anthony McGoron, Department of Biomedical Engineering and FIU Honors College, Florida International University, 10555 West Flagler Street Suite EC 2600, Miami, FL 33174

Theranostics combine diagnostic and therapeutic agents to both treat and provide feedback on the uptake and effectiveness of chemotherapeutic agents. The penetration and uptake of nanoparticles by tumor tissue is a crucial part of cancer therapeutics, as only approximately 5% of anticancer drugs are delivered to tumor tissue following systemic administration. Drug delivery of nanoparticles is enhanced by the enhanced permeability and retention effect, consisting of the facilitation of passively targeted drug delivery due to poor lymphatic drainage and vascular leakage of tumor tissue. Nevertheless, the poor diffusion and uptake of drugs into the target tumor tissue due to various factors--notably the tumor microenvironment--may result in an increased incidence of side effects and hampered clinical outcomes as well as patient quality of life.  The construction of an extracellular matrix (ECM) mimic platform that recapitulates the elements that influence drug transport is an attractive, cost-effective way to quantify the in vitro diffusion of drugs to target tissues. In previous endeavors, Nanoparticles have been previously conjugated to various elements to modify their pharmacokinetics in an effort to enhance their delivery to target tissues. Through the application of fluorescent microscopy techniques, The diffusion of fluorescein (FITC) conjugated, 3-(aminopropyl)triethoxysilane (APTES) nanoparticles through a three-dimensional, tumor extracellular matrix hydrogel mimic was investigated to devise a mathematical model that describes the mass transport of these nanoparticles through the tumor ECM model. This model was useful in providing an approximation of the pharmacokinetics of these nanoparticles through the typical medium of the tumor microenvironment.

Additional Abstract Information

Presenter: Lyan Basora Dorville

Institution: Florida International University

Type: Poster

Subject: Biological & Chemical Engineering

Status: Approved

Time and Location

Session: Poster 2
Date/Time: Mon 3:00pm-4:00pm
Session Number: 2548